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Are defined at the time of division of the parent cell.

This finding suggests something surprising: the instructions that a daughter needs stem cell for regeneration or for maintaining tissue structure begin to differentiate, are defined at the time of division of the parent cell.

Elimination smedwi-2 leads unamputated not only to a assemble assemble a regenerative response after amputation, but also to the subsequent decline animals along a reproducible set of events, ie, regression of the head top, rolling body and tissue disintegration. These defects are very similar to what is observed with her ability stem cells destroyed by lethal doses of irradiation. The essential difference, however, is that the irradiation-like defects occur observed in animals without smedwi-2, although the stem cells still present in the organism. Continue reading

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